Suppression of atherosclerosis by synthetic REV-ERB agonist
نویسندگان
چکیده
منابع مشابه
Regulation of adipogenesis by natural and synthetic REV-ERB ligands.
The nuclear hormone receptor, REV-ERB, plays an essential role in adipogenesis. Rev-erbalpha expression is induced in 3T3-L1 cells during adipogenesis, and overexpression of this receptor leads to expression of adipogenic genes. We recently demonstrated that the porphyrin heme functions as a ligand for REV-ERB, and binding of heme is required for the receptor's activity. We therefore hypothesiz...
متن کاملRegulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
The circadian clock acts at the genomic level to coordinate internal behavioural and physiological rhythms via the CLOCK–BMAL1 transcriptional heterodimer. Although the nuclear receptors REV-ERB-a and REV-ERB-b have been proposed to form an accessory feedback loop that contributes to clock function, their precise roles and importance remain unresolved. To establish their regulatory potential, w...
متن کاملDirect Regulation of CLOCK Expression by REV-ERB
Circadian rhythms are regulated at the cellular level by transcriptional feedback loops leading to oscillations in expression of key proteins including CLOCK, BMAL1, PERIOD (PER), and CRYPTOCHROME (CRY). The CLOCK and BMAL1 proteins are members of the bHLH class of transcription factors and form a heterodimer that regulates the expression of the PER and CRY genes. The nuclear receptor REV-ERBα ...
متن کاملsuppression of coke formation in thermal cracking by coke inhibitors
the main purpose of this research was to:1.develop a coking model for thermal cracking of naphtha.2.study coke inhibition methods using different coke inhibitors.developing a coking model in naphtha cracking reactors requires a suitable model of the thermal cracking reactor based on a reliable kinetic model.to obtain reliable results all these models shall be solved simultaneously.for this pu...
15 صفحه اولRev-erb- : an integrator of circadian rhythms and metabolism
Duez H, Staels B. Rev-erb: an integrator of circadian rhythms and metabolism. J Appl Physiol 107: 1972–1980, 2009. First published August 20, 2009; doi:10.1152/japplphysiol.00570.2009.—The endogenous circadian clock ensures daily rhythms in diverse behavioral and physiological processes, including locomotor activity and sleep/wake cycles, but also food intake patterns. Circadian rhythms are gen...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2015
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2015.03.070